-transparent.png){kind=logo}
A 23-year-old male patient with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) was treated with both IFN alpha and IFN gamma. Normalization of leukocyte counts was reached after 3 months of treatment. Southern blot analysis failed to detect the neoplastic cell clone after 19 months of therapy. Cytogenetically, complete suppression of Ph positive cells in the patient's bone marrow and blood was observed after 20 months and 25 months, respectively. This response was achieved with doses of IFN alpha and IFN gamma which were considerably lower than the dosage of IFN used in single agent therapy of CML.
Related Publications
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
August 1988,
The American journal of the medical sciences,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1988,
Cancer treatment reviews,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1991,
Nouvelle revue francaise d'hematologie,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1989,
Haematology and blood transfusion,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1988,
Seminars in hematology,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
March 1988,
British journal of clinical practice. Supplement,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1989,
Bone marrow transplantation,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1993,
Leukemia & lymphoma,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1999,
Voprosy onkologii,
O Kloke, and
D May, and
U Wandl, and
R Becher, and
B Opalka, and
U Beer, and
N Niederle
January 1998,
Archivum immunologiae et therapiae experimentalis,
