BIOMAT Database Logo BIOMAT Database Logo

[Continuous hepatic arterial infusion chemotherapy using implantable reservoir in liver metastases from colorectal cancer]. 1990

K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
2nd Dept. of Surgery, School of Medicine, Yokohama City University.

Continuous hepatic arterial infusion chemotherapy using implantable reservoir was performed for liver metastases from colorectal cancer, and the therapeutic effects, side effects, and complications were evaluated. 9 patients with unresectable liver metastases were as follows, 1. Group A; 3 patients, MMC 2 mg.one shot + 5-FU 250 mg/day.continuous infusion x 14 days, and then 5-FU tablets 150 mg/day.p.o. x 14 days, 2. Group B; 4 patients, MMC 2 mg.one shot + 5-FU 500 mg/day.continuous infusion x 7 days, and then 5-FU tablets 150 mg/day.p.o. x 14 days, 3. Group C; 2 patients, 5-FU 500 mg/day.continuous infusion x 14 days, and then free from agents for 14 days. In 2 of 3 group A patients, the catheters became dislocated and one died of perforation of duodenum. In group A and group B, no severe side effects were noted. But both of group C patients showed nausea, vomiting and diarrhea. In 8 of 9 patients (89%), serum CEA level fell below the preoperative level. In 4 of 7 patients who underwent CT scan, the size of the tumor regressed. Total infused dose of 5-FU was 8.17 +/- 7.56 g in group A, 16.9 +/- 2.88 g in group B, and 21.0 +/- 9.90 g in group C on average. In 2 patients of group B, therapy was repeated seven times.

UI MeSH Term Description Entries
D007261 Infusions, Intra-Arterial Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease. Infusions, Regional Arterial,Infusions, Intra Arterial,Infusions, Intraarterial,Arterial Infusion, Intra,Arterial Infusion, Regional,Arterial Infusions, Intra,Arterial Infusions, Regional,Infusion, Intra Arterial,Infusion, Intra-Arterial,Infusion, Intraarterial,Infusion, Regional Arterial,Intra Arterial Infusion,Intra Arterial Infusions,Intra-Arterial Infusion,Intra-Arterial Infusions,Intraarterial Infusion,Intraarterial Infusions,Regional Arterial Infusion,Regional Arterial Infusions
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008937 Mitomycins A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002272 Carcinoembryonic Antigen A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment. Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D005472 Fluorouracil A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. 5-FU,5-FU Lederle,5-FU Medac,5-Fluorouracil,5-Fluorouracil-Biosyn,5-HU Hexal,5FU,Adrucil,Carac,Efudex,Efudix,Fluoro-Uracile ICN,Fluoroplex,Fluorouracil Mononitrate,Fluorouracil Monopotassium Salt,Fluorouracil Monosodium Salt,Fluorouracil Potassium Salt,Fluorouracil-GRY,Fluorouracile Dakota,Fluorouracilo Ferrer Far,Fluoruracil,Fluracedyl,Flurodex,Haemato-FU,Neofluor,Onkofluor,Ribofluor,5 FU Lederle,5 FU Medac,5 Fluorouracil,5 Fluorouracil Biosyn,5 HU Hexal,Dakota, Fluorouracile,Fluoro Uracile ICN,Fluorouracil GRY,Haemato FU
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000971 Antineoplastic Combined Chemotherapy Protocols The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form. Anticancer Drug Combinations,Antineoplastic Agents, Combined,Antineoplastic Chemotherapy Protocols,Antineoplastic Drug Combinations,Cancer Chemotherapy Protocols,Chemotherapy Protocols, Antineoplastic,Drug Combinations, Antineoplastic,Antineoplastic Combined Chemotherapy Regimens,Combined Antineoplastic Agents,Agent, Combined Antineoplastic,Agents, Combined Antineoplastic,Anticancer Drug Combination,Antineoplastic Agent, Combined,Antineoplastic Chemotherapy Protocol,Antineoplastic Drug Combination,Cancer Chemotherapy Protocol,Chemotherapy Protocol, Antineoplastic,Chemotherapy Protocol, Cancer,Chemotherapy Protocols, Cancer,Combinations, Antineoplastic Drug,Combined Antineoplastic Agent,Drug Combination, Anticancer,Drug Combination, Antineoplastic,Drug Combinations, Anticancer,Protocol, Antineoplastic Chemotherapy,Protocol, Cancer Chemotherapy,Protocols, Antineoplastic Chemotherapy,Protocols, Cancer Chemotherapy
D015179 Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI. Colorectal Cancer,Colorectal Carcinoma,Colorectal Tumors,Neoplasms, Colorectal,Cancer, Colorectal,Cancers, Colorectal,Carcinoma, Colorectal,Carcinomas, Colorectal,Colorectal Cancers,Colorectal Carcinomas,Colorectal Neoplasm,Colorectal Tumor,Neoplasm, Colorectal,Tumor, Colorectal,Tumors, Colorectal

Related Publications

K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Hepatic arterial infusion chemotherapy using totally implantable reservoir in liver metastases in colorectal cancer].
August 1989, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Effects and complications of continuous hepatic arterial infusion chemotherapy using implantable reservoir for liver metastases from colorectal cancer].
August 1991, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Hepatic arterial infusion chemotherapy using implantable reservoir in colorectal liver metastasis].
August 1990, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Intra-arterial infusion chemotherapy using an implantable reservoir in the treatment of hepatic metastases in colorectal cancer].
August 1991, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Hepatic arterial infusion chemotherapy for liver metastases from colorectal cancer].
December 2000, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Evaluation of hepatic arterial infusion chemotherapy using reservoir for liver metastases from gastric cancer].
July 1998, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Arterial infusion cancer chemotherapy in liver tumor using implantable reservoir].
August 1989, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Treatment of liver metastases from colorectal cancer--major hepatic resection and continuous hepatic arterial infusion chemotherapy].
April 1990, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
[Hepatic arterial infusion chemotherapy for colorectal liver metastases].
May 2004, Gan to kagaku ryoho. Cancer & chemotherapy,
K Iijima, and S Ohki, and T Joh, and S Nakajima, and S Imai, and K Matsuo, and Y Hamahata, and S Yamaguchi, and M Fukano, and S Tsuchiya
Hepatic arterial infusion of chemotherapy for hepatic metastases from colorectal cancer.
January 2006, Cancer control : journal of the Moffitt Cancer Center,
Copied contents to your clipboard!