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Different spontaneous pulmonary metastasis inhibitions against lewis lung carcinoma in mice by bisdioxopiperazine compounds of different treatment schedules. 2010
Da-Yong Lu, and
Fu-Geng Wu, and
Zu-Ming Zhen, and
Ting-Ren Lu, and
Hong-Ying Wu, and
Jin-Yu Che, and
Bin Xu
Shanghai University, Shanghai 200444, PR China. ludayong@sh163.net
Spontaneous neoplasm metastasis, a fatalist pathological feature of cancer, is a long-evolving, multi-steps process that can now only be treated or controlled by drugs or immuno-modulators. As we have previously hypothesized, each drug or immuno-modulator might act differently within various stages of a metastasis. Therefore any researches helping to determine these differences will be beneficial for updating therapeutics for metastasis. In this work, we have testified this hypothesis by using a series of well-known anti-metastatic agents รข Bisdioxopiperazine compounds.
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