Biomaterial Database

Progesterone and oestradiol-17 beta receptors in the porcine myometrium during the oestrous cycle. 1990

G Thilander, and H Eriksson, and L E Edqvist, and H Rodriguez-Martinez

Department of Anatomy and Histology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.

The concentrations of the tissue receptors for oestradiol (E) and progesterone (P) in the porcine myometrium at different stages of the oestrous cycle have been investigated by in vitro binding and exchange methods. Both hormones bound to specific cytoplasmic (Rc) and nuclear (Rn) receptors proteins with high affinity. The amount of ERc did not vary significantly throughout the cycle. Significant variations in the amount of myometrial ERn were observed with high concentrations during late pro-oestrus. The amount of PRc reached a top value in early pro-oestrus. A significant increase in PRn levels was observed at early luteal phase, and it remained high during the rest of the luteal phase. The temporal relationships between the variations in levels of oestradiol and progesterone nuclear receptors in myometrial tissue and those of the circulating plasma levels were established. The data obtained in this study suggest a relationship between the changes in levels of oestradiol and progesterone myometrial binding and the uterine motility pattern during the oestrous cycle.

UI	MeSH Term	Description	Entries
D009215	Myometrium	The smooth muscle coat of the uterus, which forms the main mass of the organ.	Uterine Muscle,Muscle, Uterine,Muscles, Uterine,Uterine Muscles
D011959	Receptors, Estradiol	Cytoplasmic proteins that bind estradiol, migrate to the nucleus, and regulate DNA transcription.	Estradiol Receptors,Estradiol Receptor,Receptor, Estradiol
D011980	Receptors, Progesterone	Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.	Progesterone Receptors,Progestin Receptor,Progestin Receptors,Receptor, Progesterone,Receptors, Progestin,Progesterone Receptor,Receptor, Progestin
D004971	Estrus	The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog