-transparent.png){kind=logo}
The in vitro activity of tosufloxacin (A-61827; T-3262) against 15 clinical isolates of Chlamydia trachomatis and 31 recent clinical isolates of Neisseria gonorrhoeae, including 15 spectinomycin-resistant N. gonorrhoeae and 16 penicillinase-producing N. gonorrhoeae, was determined. Tosufloxacin was compared with doxycycline, ciprofloxacin, and temafloxacin against C. trachomatis. Susceptibility testing was performed by using McCoy cell monolayers. The in vitro activity of tosufloxacin against N. gonorrhoeae was compared with that of ciprofloxacin, temafloxacin, doxycycline, ceftriaxone, and spectinomycin by using an agar dilution method. Tosufloxacin was as active as temafloxacin against C. trachomatis (MIC for 90% of strains tested [MIC90], 0.25 microgram/ml; MBC for 90% of strains tested [MBC90], 0.25 microgram/ml) and was almost as active as doxycycline (MIC90, 0.06 microgram/ml; MBC90, 0.125 microgram/ml). Ciprofloxacin, temafloxacin, and tosufloxacin were extremely active against N. gonorrhoeae, including spectinomycin-resistant N. gonorrhoeae and penicillinase-producing N. gonorrhoeae, with MIC90s of 0.004, 0.015, and 0.008 microgram/ml, respectively. Ceftriaxone was slightly less active (MIC90, 0.03 microgram/ml), and doxycycline was the least active drug tested (MIC90, 4.0 micrograms/ml). Tosufloxacin and temafloxacin had excellent activity against the C. trachomatis and N. gonorrhoeae strains tested.
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
January 1990,
Diagnostic microbiology and infectious disease,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
December 1989,
Antimicrobial agents and chemotherapy,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
June 1990,
Antimicrobial agents and chemotherapy,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
May 1996,
The Journal of antimicrobial chemotherapy,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
January 1991,
Drugs under experimental and clinical research,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
February 1959,
Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
November 1990,
Antimicrobial agents and chemotherapy,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
November 2004,
The Journal of antimicrobial chemotherapy,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
February 1990,
Antimicrobial agents and chemotherapy,
J Segreti, and
D J Hirsch, and
A A Harris, and
K S Kapell, and
H Orbach, and
H A Kessler
September 2010,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
