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Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. 2011
Inke R König, and
Johannes Schumacher, and
Per Hoffmann, and
André Kleensang, and
Kerstin U Ludwig, and
Tiemo Grimm, and
Nina Neuhoff, and
Maike Preis, and
Darina Roeske, and
Andreas Warnke, and
Peter Propping, and
Helmut Remschmidt, and
Markus M Nöthen, and
Andreas Ziegler, and
Bertram Müller-Myhsok, and
Gerd Schulte-Körne
Institute of Medical Biometry and Statistics, University at Lübeck, Germany.
In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P = 1.00 × 10⁻⁷) and the implicated 6p-risk region spans around 10 Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits.
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