Biomaterial Database

The effects of hypertonic glucose solutions on hepatic bile formation. 1990

S C Rutishauser, and S E Millward

Department of Physiological Sciences, Medical School, University of Manchester, United Kingdom.

Bile secretion in the isolated guinea-pig liver was studied during perfusion with equi-osmolar hypertonic solutions containing either glucose, galactose, mannose, mannitol or sodium chloride. Perfusates made hypertonic with glucose, galactose or mannose decreased bile flow to the same extent and had similar effects on the ionic composition of bile: sodium, potassium and bicarbonate concentrations all increased. Mannitol had a smaller inhibitory effect and caused different changes in ionic composition: the increase in bile potassium concentration was proportionately greater; bicarbonate concentration did not change, but chloride was increased. Thus, glucose, galactose and mannose, can inhibit bile flow independently of extrinsic neural and hormonal mechanisms and exert a greater cholestatic effect than a non-metabolisable carbohydrate of similar molecular weight. The results also provide evidence for glucose reabsorption in the guinea-pig biliary tree, as shown in other species, and that galactose competes for this transport.

UI	MeSH Term	Description	Entries
D006982	Hypertonic Solutions	Solutions that have a greater osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.	Hypertonic Solution,Solution, Hypertonic,Solutions, Hypertonic
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008353	Mannitol	A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.	(L)-Mannitol,Osmitrol,Osmofundin
D008358	Mannose	A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)	D-Mannose,Mannopyranose,Mannopyranoside,D Mannose
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D005260	Female		Females
D005690	Galactose	An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.	D-Galactose,Galactopyranose,Galactopyranoside,D Galactose
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia