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Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir. 2011
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
Hôpital Bichat-Claude Bernard, Laboratoire de Virologie, 46 Rue Henri Huchard, 75018 Paris, France. charlotte.charpentier@bch.aphp.fr
We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.
Related Publications
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
March 2010,
The Journal of antimicrobial chemotherapy,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
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November 2010,
Retrovirology,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
November 2011,
AIDS (London, England),
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
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January 2014,
PloS one,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
November 2015,
The Journal of antimicrobial chemotherapy,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
October 2009,
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
January 2011,
Antiviral therapy,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
December 2011,
The Journal of antimicrobial chemotherapy,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
October 2011,
International journal of current chemistry,
Charlotte Charpentier, and
Bénédicte Roquebert, and
Olivier Delelis, and
Lucile Larrouy, and
Sophie Matheron, and
Roland Tubiana, and
Marina Karmochkine, and
Xavier Duval, and
Geneviève Chêne, and
Alexandre Storto, and
Gilles Collin, and
Antoine Bénard, and
Florence Damond, and
Jean-François Mouscadet, and
Françoise Brun-Vézinet, and
Diane Descamps, and
October 2008,
Clinical therapeutics,
