Neuropeptide receptors as possible targets for development of insect pest control agents. 2010

Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
Zoological Institute, Katholieke Unversitet Leuven, Belgium.

Vaious insect species have a severe impact on human welfare and environment and thus force us to continuously develop novel agents for pest control. Neuropeptides constitute a very versatile class of bioactive messenger molecules that initiate and/or regulate a wide array of vital biological processes in insects by acting on their respective receptors in the plasmamembrane of target cells. These receptors belong to two distinct categories of signal transducing proteins, i.e., heptahelical or G protein-coupled receptors (7TM, GPCR) and single transmembrane containing receptors. An increasing amount ofevidence indicates that insect neuropeptide-receptor couples play crucial roles in processes as diverse as development, metabolism, ecdysis and reproduction. As such, they gain growing interest as promising candidate targets for the development of a new generation of species- and receptor-specific insect control agents that may generate fewer side effects. In this chapter, we will present some examples of insect neuropeptide receptors and aim to demonstrate their fundamental importance in insect biology.

UI MeSH Term Description Entries
D007306 Insecticides Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. Insecticide
D007313 Insecta Members of the phylum ARTHROPODA composed or organisms characterized by division into three parts: head, thorax, and abdomen. They are the dominant group of animals on earth with several hundred thousand different kinds. Three orders, HEMIPTERA; DIPTERA; and SIPHONAPTERA; are of medical interest in that they cause disease in humans and animals. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p1). Insects,Insect
D010571 Pest Control The reduction or regulation of the population of noxious, destructive, or dangerous plants, insects, or other animals. This includes control of plants that serve as habitats or food sources for animal pests. Pest Management,Control, Pest,Management, Pest
D011956 Receptors, Cell Surface Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands. Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D011972 Receptor, Insulin A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE. Insulin Receptor,Insulin Receptor Protein-Tyrosine Kinase,Insulin Receptor alpha Subunit,Insulin Receptor beta Subunit,Insulin Receptor alpha Chain,Insulin Receptor beta Chain,Insulin-Dependent Tyrosine Protein Kinase,Receptors, Insulin,Insulin Receptor Protein Tyrosine Kinase,Insulin Receptors
D004331 Drosophila melanogaster A species of fruit fly frequently used in genetics because of the large size of its chromosomes. D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017981 Receptors, Neurotransmitter Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses. Neurohumor Receptors,Neuromediator Receptors,Neuromodulator Receptors,Neuroregulator Receptors,Receptors, Neurohumor,Receptors, Synaptic,Synaptic Receptor,Synaptic Receptors,Neuromediator Receptor,Neuromodulator Receptor,Neuroregulator Receptor,Neurotransmitter Receptor,Receptors, Neuromediators,Receptors, Neuromodulators,Receptors, Neuroregulators,Receptors, Neurotransmitters,Neuromediators Receptors,Neuromodulators Receptors,Neuroregulators Receptors,Neurotransmitter Receptors,Neurotransmitters Receptors,Receptor, Neuromediator,Receptor, Neuromodulator,Receptor, Neuroregulator,Receptor, Neurotransmitter,Receptor, Synaptic,Receptors, Neuromediator,Receptors, Neuromodulator,Receptors, Neuroregulator
D018013 Receptors, Neuropeptide Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system. Neuropeptide Receptors,Neuropeptide Receptor,Receptors, Neuropeptides,Neuropeptides Receptors,Receptor, Neuropeptide

Related Publications

Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
September 2008, Invertebrate neuroscience : IN,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
January 2019, Advances in experimental medicine and biology,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
January 2010, Advances in experimental medicine and biology,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
January 2018, Frontiers in physiology,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
May 2002, Current medicinal chemistry,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
April 2009, Annals of the New York Academy of Sciences,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
August 2021, Current opinion in biotechnology,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
July 2002, Current topics in medicinal chemistry,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
January 1999, Annals of the New York Academy of Sciences,
Matthias B Van Hiel, and Tom Van Loy, and Jeroen Poels, and Hans Peter Vandersmissen, and Heleen Verlinden, and Liesbeth Badisco, and Jozef Vanden Broeck
August 1977, Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete,
Copied contents to your clipboard!