6,7,9,10-Tetra-hydro-16,22-ethano-oxyethano-5,8,11,19-tetra-oxa-16,22-diaza-dibenzo[h,q]cyclo-octa-decine-17,21-dione: a benzyl-annelated macrobicyclic diamide. 2008

Gary L N Smith, and Yang Lei, and Douglas R Powell, and Richard W Taylor

The macrobicyclic title compound, C(24)H(28)N(2)O(7), has two tertiary diamide bridgehead atoms and is composed of a 12-membered ring (N(2)O(2) donor set) and two 18-membered rings (N(2)O(4) donor sets). The solid-state structure shows that each of the amide groups is not coplanar with the adjacent benzene ring and NMR studies indicate that this conformational relationship persists in solution.

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