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The effects of ethanol on pepsinogen release from isolated guinea pig gastric chief cells were investigated. Ethanol, at concentrations of 300 mM to 900 mM, dose-dependently stimulated increases in pepsinogen release, initial Ca influx rate and intracellular free Ca concentration ([Ca2+]i) without affecting chief cells' viability. The increases in all parameters were inhibited by La3+ or EGTA, but not by nifedipine or verapamil. COOH-terminal octapeptide of cholecystokinin (CCK8) also stimulated increases in pepsinogen release, initial Ca influx rate and [Ca2+]i. However, the increases were dependent on not only extracellular Ca2+ but also intracellular Ca2+ mobilization. These results suggest that ethanol stimulates Ca2+ influx via the mechanism different from that of CCK8 and thereby stimulates pepsinogen release from isolated guinea pig gastric chief cells.
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
August 1991,
Gastroenterology,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
January 1995,
Life sciences,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
July 1984,
The American journal of physiology,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
January 1992,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
April 1993,
Gastroenterology,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
October 1996,
Gastroenterology,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
January 1995,
Peptides,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
November 1990,
The American journal of physiology,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
October 1992,
The American journal of physiology,
Y Konda, and
C Sakamoto, and
H Nishisaki, and
O Nakano, and
K Matsuda, and
K Wada, and
M Nagao, and
T Matozaki
December 1998,
Digestive diseases and sciences,
