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The effect of prolonged salbutamol administration on beta-adrenoceptor function in asthma has been examined. Six adult patients received salbutamol tablets (16 mg daily) for between 4 and 20 weeks and six adolescents received salbutamol aerosol (800 microgram daily) for 2--5 weeks. Before and after the treatment period the acute bronchodilator response to inhaled salbutamol and the ability of inhaled salbutamol to protect against exercise-induced asthma were examined. Lymphocyte beta-adrenoceptor function was also measured in the patients on tablet therapy. Inhaled salbutamol was less effective in protecting against exercise-induced asthma at the end of the treatment period in the patients who had received tablet therapy, but otherwise there was no significant change in beta-receptor function of either airways or lymphocytes. This apparent loss of efficacy of inhaled salbutamol in the prevention of exercise-induced asthma in some subjects, even when its acute bronchodilator effect is preserved, might reflect differences in the susceptibility of different beta-adrenoceptors to desensitization after prolonged stimulation: its clinical importance remains uncertain.
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
January 1976,
Scandinavian journal of respiratory diseases,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
September 1996,
Trends in pharmacological sciences,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
October 1985,
Chest,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
November 1983,
The Journal of physiology,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
June 1986,
Anesthesiology,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
February 1978,
Pneumonologia polska,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
July 1991,
The American journal of cardiology,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
June 2010,
Current opinion in pharmacology,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
August 1979,
British journal of clinical pharmacology,
G J Gibson, and
J K Greenacre, and
P König, and
M E Conolly, and
N B Pride
February 1989,
British journal of clinical pharmacology,
