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The authors studied antiviral resistance of murine cells L-929 following single introduction into them of homologous and heterologous informative RNA preparations for antiviral protein (i-RNA-AVP). As shown, in using homologous i-RVA-AVP preparations suppression of the virus production constituted 90--93%, and was stably traced in cell passage in the course of 1 1/2 months (observation period). Following cell contact with heterologous i-RNA-AVP preparations suppression the first 6 passages of the virus production constituted about 90%, rising by the 16th passage to 99.9%. The data obtained pointed to the possibility of stable increase of cell antiviral resistance with the aid of i-RNA-AVP, this could serve as a new effective method of nonspecific cell protection from the viruses.
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F I Ershov, and
A A Kadyrova, and
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L A Bukata, and
V M Zhdanov
February 1973,
Proceedings of the National Academy of Sciences of the United States of America,
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Cancer research,
