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Hypophysectomy was performed in 28 women with Stage IV breast cancer who were treated initially with antiestrogens. Six of 13 patients who responded to tamoxifen and 2 of 12 who failed to benefit from tamoxifen obtained remissions from hypophysectomy. The remissions average 11+ months. Three of 8 patients treated initially with antiestrogens have responded to androgen therapy. The results suggest that hormones other than estrogen, which appears to play a major role, may be involved in stimulating the growth of some human breast cancers. Prolactin receptors were detectable in 51% of human breast cancers and were detected in both estrogen receptor-positive and -negative tumors. Preliminary clinical correlations suggest that prolactin receptors will not be useful in predicting response to antiestrogen therapy.
O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
October 2002,
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O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
June 1977,
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O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
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O H Pearson, and
A Manni, and
M Chambers, and
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J S Marshall
January 1982,
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O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
January 1957,
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O H Pearson, and
A Manni, and
M Chambers, and
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J S Marshall
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O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
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O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
July 2001,
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O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
August 1988,
Pharmacology & toxicology,
O H Pearson, and
A Manni, and
M Chambers, and
J Brodkey, and
J S Marshall
April 1967,
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