-transparent.png){kind=logo}
We have investigated the mechanisms by which dexamethasone (a synthetic glucocorticoid) stimulates the production of mouse mammary tumor virus (MMTV) by cell cultures derived from mammary carcinomas of GR mice. Treatment of these cells with dexamethasone stimulates a rapid accumulation of intracellular virus-specific RNA which is dependent upon RNA synthesis but not upon DNA or protein synthesis. The effect of dexamethasone is probably mediated by a specific and saturable glucocorticoid receptor. We conclude that the accumulation of MMTV RNA is a primary response to dexamethasone and that the rate of synthesis of MMTV RNA is probably accelerated by treatment with dexamethasone.
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
December 1981,
Journal of virology,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
January 1983,
Recent progress in hormone research,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
January 1976,
Virology,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
January 1975,
Cold Spring Harbor symposia on quantitative biology,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
February 1994,
Biochemical and biophysical research communications,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
October 1985,
European journal of biochemistry,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
December 1979,
Biochimica et biophysica acta,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
December 1977,
FEBS letters,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
May 1975,
The Journal of biological chemistry,
G M Ringold, and
K R Yamamoto, and
G M Tomkins, and
M Bishop, and
H E Varmus
January 1993,
Molecular endocrinology (Baltimore, Md.),
