-transparent.png){kind=logo}
Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents. 2011
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
We report the synthesis, anti-inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave-assisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.
Related Publications
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
August 2022,
Current computer-aided drug design,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
June 2012,
Archives of pharmacal research,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
February 2014,
Molecules (Basel, Switzerland),
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
January 2023,
Current drug discovery technologies,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
July 2020,
Molecules (Basel, Switzerland),
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
February 2016,
Archiv der Pharmazie,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
September 2014,
Fitoterapia,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
May 2018,
Journal of medicinal chemistry,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
January 2017,
Current pharmaceutical design,
Asunción Burguete, and
Eleni Pontiki, and
Dimitra Hadjipavlou-Litina, and
Saioa Ancizu, and
Raquel Villar, and
Beatriz Solano, and
Elsa Moreno, and
Enrique Torres, and
Silvia Pérez, and
Ignacio Aldana, and
Antonio Monge
September 2009,
Bioorganic & medicinal chemistry letters,
