Adiponectin is an adipose tissue derived mediator with significant anti atherosclerotic properties and is involved in the regulation of insulin sensitivity and lipid oxidation, a few studies were done in acute phase of myocardial infarction, especially in none obese patients. The study investigated the association between adiponectin concentration and acute phase of myocardial infarction (MI) in non obese men patients. The results showed that adiponectin levels in patients with AMI (5.2ug/ml) were significantly lower than that of control group (7.5ug/ml) (P<0.001). Lower adiponectin levels were independently associated with higher risk of AMI (odd ratio= 6.12, 95%CIs: 2.4- 18.6; P=<0.001).Adiponectin levels were negatively correlated with triglyceride (r=-0.34) in case group and (r=- 0.41) in control group (P< 0.001). In addition, negatively correlated with BMI(r=-0.27) in case group and (r=-0.23) in control group (P< 0.001), but adiponectin levels is positively correlated with HDL-Cholesterol (r= 0.45) in case group and (r=0.51) in control group with (P<0.001).