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Mice could be significantly protected against infection with herpes simplex virus (HSV) by i.p. or i.v. injection of killed Corynebacterium parvum 7 days before infection. This protection was seen in inbred strains of mice with a different degree of sensitivity to HSV and after both i.p. and i.v. infection. Resistant mice immunosuppressed by X-irradiation and showing an increased susceptibility to HSV could also be protected by a previous injection of C. parvum. Elevated levels of interferon were demonstrated in the serum of mice injected with C. parvum 5 to 12 days previously. Four different strains of anaerobic coryneforms were compared and only those which were able to induce a systemic activation of the lymphoreticular system (as reflected by splenomegaly) protected against HSV infection. Protection against HSV-infection could also be demonstrated by using killed Bordetella pertussis. C. parvum also protected against Semliki Forest virus infection in two different strains of mice.
H Kirchner, and
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H M Hirt, and
K Munk
April 1977,
Infection and immunity,
H Kirchner, and
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H M Hirt, and
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January 1985,
Developments in biological standardization,
H Kirchner, and
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K Munk
August 1989,
Vaccine,
H Kirchner, and
M T Scott, and
H M Hirt, and
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March 1978,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin,
H Kirchner, and
M T Scott, and
H M Hirt, and
K Munk
June 1981,
Infection and immunity,
H Kirchner, and
M T Scott, and
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K Munk
June 1983,
Cellular immunology,
H Kirchner, and
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H M Hirt, and
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August 2001,
Infection and immunity,
H Kirchner, and
M T Scott, and
H M Hirt, and
K Munk
January 1992,
Vaccine,
H Kirchner, and
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H M Hirt, and
K Munk
January 1983,
Natural immunity and cell growth regulation,
H Kirchner, and
M T Scott, and
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K Munk
January 1993,
Vaccine,
