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[The interferon status in helminthiases. 2. Alveolar hydatid disease]. 1990

S N Suntsov, and N N Ozeretskovskaia, and S S Grigorian, and A M Shcherbakov, and F I Ershov

In 11 patients with Echinococcus multilocularis infection the blood levels of alpha-interferon (alpha-IF) and gamma-interferon (gamma-IF) were measured using vesical stomatitis virus culture. In patients with the disease the contents of alpha- and gamma-IF were significantly (p less than 0.01) lower than in healthy controls: 392 +/- 101.6 and 101.6 +/- 20.9 U/ml and 1024 +/- 83.2 and 187 +/- 16.9 U/ml, respectively. The lower levels of alpha- and gamma-IF were found in patients with multiorgan damages including the lungs, as compared with the liver and abdomen infestation: alpha-IF 160 +/- 56.6, gamma-IF 88 +/- 24.0 and 525.7 +/- 124.3 and 109 +/- 18.3 (p less than 0.01), respectively. The similar data have been found in patients with hydatid disease (S. N. Suntsov et al., 1990). After 5 to 6 courses of mebendazole therapy in a dose of 50 mg/kg body weight dai y for 30 days with 30-day intervals there was a tendency to a slight elevation of cytokines levels (S. N. Suntsov et al., 1990), as seen in hydatid disease. The estimation of IF levels in multilocular echinococcosis infection may be of prognostic value and perhaps for the evaluation of the efficacy of surgical and chemotherapeutic treatment.

UI MeSH Term Description Entries
D007370 Interferon Type I Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA). Interferons Type I,Type I Interferon,Type I Interferons,Interferon, Type I,Interferons, Type I
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D004444 Echinococcosis, Hepatic Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST). Alveolar Echinococcosis, Hepatic,Echinococcosis, Hepatic Alveolar,Hydatid Cyst, Hepatic,Hydatidosis, Hepatic,Cyst, Hepatic Hydatid,Cysts, Hepatic Hydatid,Hepatic Alveolar Echinococcosis,Hepatic Echinococcosis,Hepatic Hydatid Cyst,Hepatic Hydatid Cysts,Hepatic Hydatidosis,Hydatid Cysts, Hepatic
D004445 Echinococcosis, Pulmonary Helminth infection of the lung caused by Echinococcus granulosus or Echinococcus multilocularis. Hydatid Cyst, Pulmonary,Hydatidosis, Pulmonary,Cyst, Pulmonary Hydatid,Cysts, Pulmonary Hydatid,Echinococcoses, Pulmonary,Hydatid Cysts, Pulmonary,Hydatidoses, Pulmonary,Pulmonary Echinococcoses,Pulmonary Echinococcosis,Pulmonary Hydatid Cyst,Pulmonary Hydatid Cysts,Pulmonary Hydatidoses,Pulmonary Hydatidosis
D005260 Female Females
D006373 Helminthiasis Infestation with parasitic worms of the helminth class. Nematomorpha Infections,Infections, Nematomorpha,Helminthiases,Infection, Nematomorpha,Nematomorpha Infection
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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