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The in vitro activity of sparfloxacin, a new quinolone, was compared with those of ciprofloxacin and fleroxacin against gram-positive and gram-negative bacteria, greater than 90% of which were isolated from blood culture specimens of cancer patients. Sparfloxacin was extremely active against Acinetobacter species, Aeromonas hydrophila, Citrobacter diversus, Enterobacter species, Escherichia coli, Klebsiella species, Proteus vulgaris, and Serratia marcescens (inhibiting greater than 90% of these isolates at a concentration of 0.5 microgram/ml) and moderately active against Pseudomonas species, other Proteus species, and Citrobacter freundii. Sparfloxacin inhibited greater than 90% of staphylococci (including methicillin-resistant and coagulase-negative strains) at a concentration of 0.12 microgram/ml and greater than 90% of streptococci (including Streptococcus pneumoniae) at a concentration of 1.0 microgram/ml. It was also active against Bacillus cereus, Enterococcus species, and Corynebacterium jeikeium, organisms that have become fairly common in cancer patients.
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
April 1990,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
January 1990,
Diagnostic microbiology and infectious disease,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
September 1990,
Antimicrobial agents and chemotherapy,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
January 1991,
Diagnostic microbiology and infectious disease,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
January 1991,
Diagnostic microbiology and infectious disease,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
January 1991,
Diagnostic microbiology and infectious disease,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
November 1990,
Antimicrobial agents and chemotherapy,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
February 1992,
Antimicrobial agents and chemotherapy,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
November 1990,
Antimicrobial agents and chemotherapy,
K V Rolston, and
H Nguyen, and
M Messer, and
B LeBlanc, and
D H Ho, and
G P Bodey
February 1992,
Journal of chemotherapy (Florence, Italy),
