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Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study. 2011

Bruce H Haughey, and Michael L Hinni, and John R Salassa, and Richard E Hayden, and David G Grant, and Jason T Rich, and Simon Milov, and James S Lewis, and Murli Krishna
Department of Otolaryngology-Head and Neck Surgery Washington University School of Medicine, St. Louis, Missouri, USA. haugheyb@ent.wustl.edu

BACKGROUND Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma. METHODS A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996-2006 at 3 centers with minimum 2-year follow-up was analyzed. Survival, locoregional control, and swallowing status were recorded. RESULTS Mean follow-up was 49 months and 79.4% of patients were alive. Three-year overall survival, disease-specific survival, and disease-free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia. CONCLUSIONS TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency.

UI MeSH Term Description Entries
D008297 Male Males
D008866 Microsurgery The performance of surgical procedures with the aid of a microscope.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009959 Oropharyngeal Neoplasms Tumors or cancer of the OROPHARYNX. Cancer of Oropharnyx,Oropharyngeal Cancer,Cancer of the Oropharynx,Neoplasms, Oropharyngeal,Oropharynx Cancer,Oropharynx Neoplasms,Cancer, Oropharyngeal,Cancer, Oropharynx,Cancers, Oropharyngeal,Cancers, Oropharynx,Neoplasm, Oropharyngeal,Neoplasm, Oropharynx,Neoplasms, Oropharynx,Oropharnyx Cancer,Oropharnyx Cancers,Oropharyngeal Cancers,Oropharyngeal Neoplasm,Oropharynx Cancers,Oropharynx Neoplasm
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D015996 Survival Rate The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods. Cumulative Survival Rate,Mean Survival Time,Cumulative Survival Rates,Mean Survival Times,Rate, Cumulative Survival,Rate, Survival,Rates, Cumulative Survival,Rates, Survival,Survival Rate, Cumulative,Survival Rates,Survival Rates, Cumulative,Survival Time, Mean,Survival Times, Mean,Time, Mean Survival,Times, Mean Survival

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