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A total of 311 patients presenting with uncomplicated gonorrhoea were entered into a comparative randomized open-label study and given single-dose treatment with either oral cefuroxime axetil (CAE) or intramuscular procaine penicillin (PP). Neisseria gonorrhoeae was eliminated from 129 (98%) of 131 evaluable patients treated with CAE and 127 (98%) of 129 evaluable patients treated with PP. None of the 4 treatment failures (3 male and 1 female) were caused by beta-lactamase-producing isolates. Both treatments were well tolerated with minor adverse events reported in 3 (2%) of CAE treated patients. We conclude that CAE is an effective, well tolerated treatment for uncomplicated gonorrhoea which has the convenience and acceptability of single-dose oral therapy.
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
January 1988,
Scandinavian journal of infectious diseases,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
December 1983,
The British journal of venereal diseases,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
August 1984,
The British journal of venereal diseases,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
December 1983,
The British journal of venereal diseases,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
August 1986,
Genitourinary medicine,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
August 1986,
Antimicrobial agents and chemotherapy,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
December 1972,
The British journal of venereal diseases,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
March 1973,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
October 1986,
Genitourinary medicine,
G R Kinghorn, and
R C Spencer, and
T K Smith, and
P D Woolley, and
R Patel, and
A J Robinson
August 1973,
The British journal of venereal diseases,
