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To evaluate the relationship between autonomic neuropathy, and biochemical and X-ray parameters of secondary hyperparathyroidism, we examined 19 predialysis and 24 haemodialysis non-diabetic uraemic patients. Autonomic neuropathy was assessed using four tests: deep breathing, Valsalva manoeuvre, lying to standing, and postural hypotension. Serum Ca, Ca2+, P, Mg, alkaline phosphatase, iPTH, and osteocalcin were assayed. Hand X-ray was obtained to evaluate acro-osteolysis (score A) and subperiosteal resorption (score B). Ten predialysis patients (52%) and 15 haemodialysis patients (62%) showed one or more abnormal autonomic tests. Age, dialysis duration, and biochemical parameters of secondary hyperparathyroidism did not differ significantly in uraemic patients with and without abnormal autonomic tests. Furthermore, there was no significant relation between autonomic tests and iPTH or osteocalcin. Score A and score B was significantly greater in patients with abnormal tests than in patients without (P less than 0.009 and P less than 0.025). When predialysis and haemodialysis patients were considered separately the correlation between score A, score B, and autonomic neuropathy was confirmed only in haemodialysis patients. In conclusion, autonomic neuropathy does not seem to be related to the biochemical parameters of secondary hyperparathyroidism, while it appears significantly associated with the radiological signs of osteodystrophy, suggesting a possible pathogenetic linkage between autonomic neuropathy and secondary hyperparathyroidism.
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
July 1978,
Lancet (London, England),
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
January 1984,
British medical journal (Clinical research ed.),
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
January 1981,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
January 1978,
Neurologija,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
March 2011,
Danish medical bulletin,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
January 1994,
International urology and nephrology,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
January 1990,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
January 2006,
Ugeskrift for laeger,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
October 1986,
Australian and New Zealand journal of medicine,
V Spallone, and
S Mazzaferro, and
E Tomei, and
M R Maiello, and
G Lungaroni, and
D Sardella, and
D Diacinti, and
G Menzinger, and
G Coen
April 1985,
Acta neurologica Scandinavica,
