-transparent.png){kind=logo}
Proteinuria and renal xanthine metabolising enzymes, xanthine oxidase and xanthine dehydrogenase, were evaluated in Adriamycin-treated rats fed standard (21% casein) and low-protein (6% casein) diets. In rats fed a standard diet Adriamycin was associated with increased activities in the kidney of xanthine oxidase and xanthine dehydrogenase and induced massive proteinuria. The pharmacological block of both enzymes by allopurinol and tungsten block of both enzymes by allopurinol and tungsten reduced proteinuria to one-third of the original levels. Rats fed a low-protein diet presented decreased levels of renal xanthine oxidase and xanthine dehydrogenase and were only slightly proteinuric. Finally, rats shifted from a low-protein diet to a normal one developed massive proteinuria in spite of normal or slightly decreased levels of renal xanthine oxidase and xanthine dehydrogenase. We conclude that a low-protein diet is effective in decreasing the levels of xanthine metabolising enzymes that are in part responsible for the renal damage due to Adriamycin. This is not however the unique mechanism by which the low-protein diet protects against the development of proteinuria in Adriamycin nephrosis; other factors must also be hypothesised.
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
March 1978,
The Journal of the Association of Physicians of India,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
January 1988,
Contributions to nephrology,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
June 2008,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
October 2006,
The British journal of nutrition,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
January 1984,
Applied pathology,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
November 1994,
The American journal of the medical sciences,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
March 1994,
The American journal of physiology,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
July 1985,
Kidney international,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
January 1980,
Nature,
F Ginevri, and
G M Ghiggeri, and
R Oleggini, and
G Barbano, and
R Bertelli, and
G Candiano, and
F Perfumo, and
R Gusmano
December 2000,
Pediatric nephrology (Berlin, Germany),
