BIOMAT Database Logo BIOMAT Database Logo

Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex. 2011

Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Product Creation Systems, Tsukuba, Ibaraki, Japan. m2-shiotani@hhc.eisai.co.jp

Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).

UI MeSH Term Description Entries
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D005260 Female Females
D005634 Fructose-Bisphosphate Aldolase An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13. Aldolase,Fructosediphosphate Aldolase,Aldolase A,Aldolase B,Aldolase C,Fructose 1,6-Bisphosphate Aldolase,Fructose 1,6-Bisphosphate Aldolase, Class II,Fructose 1-Phosphate Aldolase,Fructose Biphosphate Aldolase,Fructosemonophosphate Aldolase,1,6-Bisphosphate Aldolase, Fructose,Aldolase, Fructose 1,6-Bisphosphate,Aldolase, Fructose 1-Phosphate,Aldolase, Fructose Biphosphate,Aldolase, Fructose-Bisphosphate,Aldolase, Fructosediphosphate,Aldolase, Fructosemonophosphate,Fructose 1 Phosphate Aldolase,Fructose 1,6 Bisphosphate Aldolase,Fructose Bisphosphate Aldolase
D000251 Adenosine Triphosphatases A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA. ATPases,Adenosinetriphosphatase,ATPase,ATPase, DNA-Dependent,Adenosine Triphosphatase,DNA-Dependent ATPase,DNA-Dependent Adenosinetriphosphatases,ATPase, DNA Dependent,Adenosinetriphosphatases, DNA-Dependent,DNA Dependent ATPase,DNA Dependent Adenosinetriphosphatases,Triphosphatase, Adenosine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014305 Triose-Phosphate Isomerase An enzyme that catalyzes reversibly the conversion of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. A deficiency in humans causes nonspherocytic hemolytic disease (ANEMIA, HEMOLYTIC, CONGENITAL NONSPHEROCYTIC). EC 5.3.1.1. Phosphotriose Isomerase,Triosephosphate Isomerase,Triosephosphate Mutase,Isomerase, Phosphotriose,Isomerase, Triose-Phosphate,Isomerase, Triosephosphate,Mutase, Triosephosphate,Triose Phosphate Isomerase
D014617 Vacuoles Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion. Vacuole
D016194 Receptors, N-Methyl-D-Aspartate A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. N-Methyl-D-Aspartate Receptor,N-Methyl-D-Aspartate Receptors,NMDA Receptor,NMDA Receptor-Ionophore Complex,NMDA Receptors,Receptors, NMDA,N-Methylaspartate Receptors,Receptors, N-Methylaspartate,N Methyl D Aspartate Receptor,N Methyl D Aspartate Receptors,N Methylaspartate Receptors,NMDA Receptor Ionophore Complex,Receptor, N-Methyl-D-Aspartate,Receptor, NMDA,Receptors, N Methyl D Aspartate,Receptors, N Methylaspartate
D016291 Dizocilpine Maleate A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects. Dizocilpine,MK-801,MK 801,MK801

Related Publications

Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Quantitative analysis of factors influencing neuronal necrosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex.
October 1995, Brain research,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Pathological effects of MK-801 in the rat posterior cingulate/retrosplenial cortex.
January 1994, Psychopharmacology bulletin,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
MK-801-induced expression of Fos protein family members in the rat retrosplenial granular cortex.
September 1999, Journal of neuroscience research,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
September 2001, Brain research,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex: prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylamine.
October 1996, Journal of neuroscience research,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex.
February 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Reactive gliosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex: GFAP evaluation by sandwich ELISA and immunocytochemistry.
January 1995, Neurotoxicology,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801.
January 1994, Acta neuropathologica,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex.
April 2000, The European journal of neuroscience,
Motohiro Shiotani, and Kyoko Nakano, and Emiko Yamauchi, and Yoshiya Oda, and Satoru Hosokawa, and Toyohiko Aoki
Increased expression of cathepsin D in retrosplenial cortex of MK-801-treated rats.
October 1997, Experimental neurology,
Copied contents to your clipboard!