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During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules. The spindle checkpoint is deactivated as chromosomes start moving toward the spindles in anaphase, but the mechanisms by which this deactivation and adaptation to prolonged mitotic arrest occur remain obscure. Our results strongly suggest that Cdc28-mediated phosphorylation of Bub1 at T566 plays an important role for the degradation of Bub1 in anaphase, and the phosphorylation is required for adaptation of the spindle checkpoint to prolonged mitotic arrest.
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
May 2003,
Molecular cell,
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
January 2014,
Genes & development,
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
January 2006,
Cell cycle (Georgetown, Tex.),
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
October 2007,
Developmental cell,
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
June 2007,
Hybridoma (2005),
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
September 2010,
Cell cycle (Georgetown, Tex.),
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
July 2005,
Cell death and differentiation,
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
August 2015,
Journal of cell science,
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
November 2008,
Molecular cell,
Greicy H Goto, and
Ashutosh Mishra, and
Rashid Abdulle, and
Clive A Slaughter, and
Katsumi Kitagawa
January 2022,
Current biology : CB,
