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Cellulose acetate membrane improves some aspects of red blood cell function in haemodialysis patients. 1990

G Sevillano, and M Rodríguez-Puyol, and R Martos, and I Duque, and S Lamas, and M L Díez-Marqués, and J Lucio, and D Rodríguez-Puyol
Department of Physiology, University of Alcalá de Henares, Madrid, Spain.

The present study was designed to evaluate the influence of two haemodialysis membranes of different biocompatibility on red blood cell function. Twelve patients were studied in two consecutive dialyses, with cuprophan and cellulose acetate. Blood was extracted at 0, 20 and 180 min after the beginning of the haemodialysis session and general haematological parameters, osmotic fragility, deformability, methaemoglobin concentration and malonyldialdehyde (MDA) red blood cell content were determined. Osmotic fragility improved with both membranes, but this improvement was more marked with cellulose acetate. MDA red blood cell content showed a tendency to increase after 3 h with cuprophan (114 +/- 11% of the basal value), whereas it tended to decrease with cellulose acetate (92 +/- 12%), the differences between the two groups being statistically significant. These results suggest that red cell function may improve by changing the characteristics of haemodialysis membranes. This phenomenon could be related to a better biocompatibility.

UI MeSH Term Description Entries
D007688 Kidneys, Artificial Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE. Artificial Kidney,Kidney, Artificial,Artificial Kidneys,Blood Dialyser,Blood Dialyzers,Hemodialyser,Hemodialyzers,Renal Dialysis Machine,Blood Dialysers,Blood Dialyzer,Dialyser, Blood,Dialysers, Blood,Dialysis Machine, Renal,Dialysis Machines, Renal,Dialyzer, Blood,Dialyzers, Blood,Hemodialysers,Hemodialyzer,Machine, Renal Dialysis,Machines, Renal Dialysis,Renal Dialysis Machines
D008297 Male Males
D008315 Malondialdehyde The dialdehyde of malonic acid. Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D008567 Membranes, Artificial Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION. Artificial Membranes,Artificial Membrane,Membrane, Artificial
D008706 Methemoglobin Ferrihemoglobin
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009996 Osmotic Fragility RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst. Saline Fragility,Fragility, Osmotic,Fragility, Saline
D002482 Cellulose A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations. Alphacel,Avicel,Heweten,Polyanhydroglucuronic Acid,Rayophane,Sulfite Cellulose,alpha-Cellulose,Acid, Polyanhydroglucuronic,alpha Cellulose
D004907 Erythrocyte Deformability Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature. Erythrocyte Filterability,Deformability, Erythrocyte,Filterability, Erythrocyte
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle

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