Propafenone hydrochloride (Rytmonorm, Prolekofen) belongs to the membranous anti-arrhythmical agents of IC group. Simultaneously, it produces a mild beta blocking effect and blocks slow Calcium channels. The mentioned agent is of current use in treating both the supraventricular and ventricular tachyarrhythmias. Literary experience is referred to in management of arrhythmias with propafenone as well as electrophysiologic properties, pharmacokinetics, hemodynamic effect and side-effects.