Biomaterial Database

Effects of fresh kola-nut extract (Cola nitida) on the locomotor activities of male mice. 1990

J S Ajarem

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

The influence of fresh Kola-nut (Gooroo-nut) extract on locomotor activity of laboratory male mice was studied using direct ethological observations. The Kola extract was injected intraperitoneally (I.P.) to the experimental animals and behavioural measures were made at 15, 30, 60 and 120 min intervals post injection. It was observed that a medium dose (5 mg/kg) significantly increased the locomotor activity whereas a low dose (2.5 mg/kg) had no effect and a high dose (10 mg/kg) showed depressive effects on the locomotor activities. The results suggest that the Kola extract induces biphasic changes in the locomotor activity of mice depending on the dose and the treatment duration.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D010936	Plant Extracts	Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.	Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus