BIOMAT Database Logo BIOMAT Database Logo

Effect of intravenously administered fat emulsion on liver function in totally depancreatized dogs. 1990

T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
Second Department of Surgery, Kinki University School of Medicine, Sayama, Japan.

Total Pancreatectomy was performed under nembutal anesthesia in 16 adult mongrel dogs after a 24-hour fast, and the depancreatized dogs were given parenteral nutrition containing fat emulsion. Serum lipids, intravenous fat tolerance and post-heparin lipolytic activity were determined and liver biopsy was done to demonstrate the presence or absence of fatty liver. The animals were divided into three groups: group A (n = 6) received fat emulsion 1 g/kg/day; group B (n = 5), fat emulsion 2 g/kg/day; and group C (n = 5), no fat emulsion. Blood levels of cholesterol and phospholipid were increased in group B, while only a mild elevation of the blood triglyceride (TG) level was noted in group A. In group C, cholesterol and phospholipid levels were decreased, and hypoglycemia was liable to occur. The rate of disappearance of blood fat (K2) was decreased two weeks after surgery in group B, but there were no significant change in the other two groups. These findings suggest that if insulin is present, the administration of fat emulsion will not cause fatty liver.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008111 Liver Function Tests Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions. Function Test, Liver,Function Tests, Liver,Liver Function Test,Test, Liver Function,Tests, Liver Function
D008297 Male Males
D010180 Pancreatectomy Surgical removal of the pancreas. (Dorland, 28th ed) Pancreatectomies
D010289 Parenteral Nutrition, Total The delivery of nutrients for assimilation and utilization by a patient whose sole source of nutrients is via solutions administered intravenously, subcutaneously, or by some other non-alimentary route. The basic components of TPN solutions are protein hydrolysates or free amino acid mixtures, monosaccharides, and electrolytes. Components are selected for their ability to reverse catabolism, promote anabolism, and build structural proteins. Hyperalimentation, Parenteral,Intravenous Hyperalimentation,Nutrition, Total Parenteral,Parenteral Hyperalimentation,Total Parenteral Nutrition,Hyperalimentation, Intravenous
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005217 Fat Emulsions, Intravenous Emulsions of fats or lipids used primarily in parenteral feeding. Intravenous Fat Emulsion,Intravenous Lipid Emulsion,Lipid Emulsions, Intravenous,Emulsion, Intravenous Fat,Emulsion, Intravenous Lipid,Emulsions, Intravenous Fat,Emulsions, Intravenous Lipid,Fat Emulsion, Intravenous,Intravenous Fat Emulsions,Intravenous Lipid Emulsions,Lipid Emulsion, Intravenous
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
Effect of exogenously administered glucagon on plasma glucose levels in totally depancreatized dogs.
January 1978, Gastroenterologia Japonica,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
Influence of estrogen on fat metabolism in totally depancreatized dogs.
January 1966, Nihon geka hokan. Archiv fur japanische Chirurgie,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
[Effect of intravenous administration of fat emulsion to depancreatized dogs].
December 1988, Nihon Geka Gakkai zasshi,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
Influence of estrogen on adrenocortical function in totally depancreatized dogs.
July 1967, Nihon geka hokan. Archiv fur japanische Chirurgie,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
The tolerance of dogs to intravenously administered fatty chyle and synthetic fat emulsion.
March 1948, Federation proceedings,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
[Studies on the transport of an intravenously administered fat emulsion].
August 1963, Medizinische Klinik,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
The disposal of intravenously administered amino acids by normal, hepatectomized, depancreatized and hyperthyroid dogs.
March 1948, Federation proceedings,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
The effect of intravenously administered fructose on the ketone bodies of the depancreatized dog.
February 1954, The Journal of pharmacology and experimental therapeutics,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
Influence of estrogen on sugar metabolism in totally depancreatized dogs.
January 1968, Nihon geka hokan. Archiv fur japanische Chirurgie,
T Sudo, and R Tsubakimoto, and M Miyamoto, and H Bessho, and H Kanazawa, and C Yasuda, and K Fukunishi, and T Uchida, and M Kawamura, and T Kuyama
[Effect of glucagon administration on blood glucose level in totally depancreatized dogs (author's transl)].
September 1976, Nihon geka hokan. Archiv fur japanische Chirurgie,
Copied contents to your clipboard!