BIOMAT Database Logo BIOMAT Database Logo

Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): comparison between male and female wild-type and 5-HT(1A) receptor knockout mice. 2011

Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Victoria, Australia. m.vandenbuuse@mhri.edu.au

The aim of this study was to investigate the involvement of serotonin-1A (5-HT(1A)) receptors in the effects of 3,4-methylenedioxymetamphetamine (MDMA) on prepulse inhibition of acoustic startle (PPI) by comparing male and female wild-type (WT) mice and 5-HT(1A) receptor knockout (1AKO) mice. MDMA dose-dependently decreased PPI in male and female mice although female mice were more sensitive at the 100-ms inter-stimulus interval (ISI). In male mice, 10 mg/kg MDMA disrupted PPI in 1AKO but not in WT controls. There was no genotype difference at higher or lower doses of MDMA. In female mice, there was no difference between genotypes at any dose of MDMA. Average startle was reduced by 10 mg/kg and 20 mg/kg MDMA similarly in male and female mice and all genotypes. These results show an involvement of 5-HT(1A) receptors in the effect of MDMA on PPI in male, but not female mice.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009433 Neural Inhibition The function of opposing or restraining the excitation of neurons or their target excitable cells. Inhibition, Neural
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D006213 Hallucinogens Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise. Hallucinogen,Hallucinogenic Agent,Hallucinogenic Drug,Hallucinogenic Substance,Psychedelic,Psychedelic Agent,Psychedelic Agents,Psychotomimetic Agent,Psychotomimetic Agents,Hallucinogenic Agents,Hallucinogenic Drugs,Hallucinogenic Substances,Psychedelics,Agent, Hallucinogenic,Agent, Psychedelic,Agent, Psychotomimetic,Agents, Hallucinogenic,Agents, Psychedelic,Agents, Psychotomimetic,Drug, Hallucinogenic,Drugs, Hallucinogenic,Substance, Hallucinogenic,Substances, Hallucinogenic
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012727 Sex Characteristics Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction. Gender Characteristics,Gender Differences,Gender Dimorphism,Sex Differences,Sex Dimorphism,Sexual Dichromatism,Sexual Dimorphism,Characteristic, Gender,Characteristic, Sex,Dichromatism, Sexual,Dichromatisms, Sexual,Difference, Sex,Dimorphism, Gender,Dimorphism, Sex,Dimorphism, Sexual,Gender Characteristic,Gender Difference,Gender Dimorphisms,Sex Characteristic,Sex Difference,Sex Dimorphisms,Sexual Dichromatisms,Sexual Dimorphisms

Related Publications

Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
5-HT1B receptor modulation of prepulse inhibition: recent findings in wild-type and 5-HT1B knockout mice.
December 1998, Annals of the New York Academy of Sciences,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing and release: comparison between dorsal and median raphe 5-HT systems.
January 1997, Neuropharmacology,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Assessing prepulse inhibition of startle in wild-type and knockout mice.
November 1999, Psychopharmacology,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Interaction between 5-HT(1A) and 5-HT(1B) receptors: effects of 8-OH-DPAT-induced hypothermia in 5-HT(1B) receptor knockout mice.
June 2001, European journal of pharmacology,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes.
January 2001, Physiology & behavior,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
The 5-HT(1A) receptor knockout mouse and anxiety.
November 2001, Behavioural pharmacology,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout mice.
July 1997, Psychopharmacology,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Disruption of the discriminative stimulus effects of S(+)-3,4-methylenedioxymethamphetamine (MDMA) by (+/-)-MDMA neurotoxicity: protection by fluoxetine.
March 1999, Behavioural pharmacology,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition.
January 2008, Biological psychiatry,
Maarten van den Buuse, and Thorsten Becker, and Perrin Kwek, and Sally Martin, and Emma Ruimschotel, and Victoria Risbrough
Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice.
September 2002, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Copied contents to your clipboard!