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The study of regional blood flow in the kidney has been fraught with difficulties. Quantitation of perfusion of the inner cortex and medulla of the kidney has been especially challenging to measure because there is no way to directly visualize the large or small blood vessels in these areas. Furthermore, there has been a lack of reliable techniques to measure tissue blood flow in the kidney. In order to appreciate fully the technical demands of measuring changes in regional blood flow within the kidney, it is necessary to first understand the complex structure of the renal microcirculation.
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