BIOMAT Database Logo BIOMAT Database Logo

Genetic approaches to the mechanism of macrophage functions. 1978

B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff

UI MeSH Term Description Entries
D007141 Immunoglobulin Fc Fragments Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN. Fc Fragment,Fc Fragments,Fc Immunoglobulin,Fc Immunoglobulins,Ig Fc Fragments,Immunoglobulin Fc Fragment,Immunoglobulins, Fc,Immunoglobulins, Fc Fragment,Fc Fragment Immunoglobulins,Fc Fragment, Immunoglobulin,Fc Fragments, Ig,Fc Fragments, Immunoglobulin,Fragment Immunoglobulins, Fc,Fragment, Fc,Fragments, Ig Fc,Immunoglobulin, Fc
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D010587 Phagocytosis The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES). Phagocytoses
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003176 Complement C3 A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase. C3 Complement,C3 Precursor,Complement 3,Complement C3 Precursor,Complement Component 3,Precursor-Complement 3,Pro-C3,Pro-Complement 3,C3 Precursor, Complement,C3, Complement,Complement, C3,Component 3, Complement,Precursor Complement 3,Precursor, C3,Precursor, Complement C3,Pro C3,Pro Complement 3
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D006822 Hybrid Cells Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION. Somatic Cell Hybrids,Cell Hybrid, Somatic,Cell Hybrids, Somatic,Cell, Hybrid,Cells, Hybrid,Hybrid Cell,Hybrid, Somatic Cell,Hybrids, Somatic Cell,Somatic Cell Hybrid
D000242 Cyclic AMP An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. Adenosine Cyclic 3',5'-Monophosphate,Adenosine Cyclic 3,5 Monophosphate,Adenosine Cyclic Monophosphate,Adenosine Cyclic-3',5'-Monophosphate,Cyclic AMP, (R)-Isomer,Cyclic AMP, Disodium Salt,Cyclic AMP, Monoammonium Salt,Cyclic AMP, Monopotassium Salt,Cyclic AMP, Monosodium Salt,Cyclic AMP, Sodium Salt,3',5'-Monophosphate, Adenosine Cyclic,AMP, Cyclic,Adenosine Cyclic 3',5' Monophosphate,Cyclic 3',5'-Monophosphate, Adenosine,Cyclic Monophosphate, Adenosine,Cyclic-3',5'-Monophosphate, Adenosine,Monophosphate, Adenosine Cyclic
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining

Related Publications

B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
[Feasibilities of genetic approaches to the brain functions].
April 1995, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Genetic regulation of macrophage functions.
January 1976, Advances in experimental medicine and biology,
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Genetic approaches to the cellular functions of polyamines in mammals.
March 2004, European journal of biochemistry,
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Genetic and genomic approaches to understanding macrophage identity and function.
April 2015, Arteriosclerosis, thrombosis, and vascular biology,
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Cigarette smoke extract interferes with placenta macrophage functions: A new mechanism to compromise placenta functions?
June 2018, Reproductive toxicology (Elmsford, N.Y.),
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Genetic modification of macrophage functions in relation to antibody responsiveness and resistance to infection.
January 1979, Advances in experimental medicine and biology,
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Tuning up the right signal: chemical and genetic approaches to study GPCR functions.
April 2014, Current opinion in cell biology,
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
New approaches to macrophage function.
August 1980, Kekkaku : [Tuberculosis],
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
Genetic approaches in the study of heparan sulfate functions in Drosophila.
January 2015, Methods in molecular biology (Clifton, N.J.),
B R Bloom, and B Diamond, and R Muschel, and N Rosen, and J Schneck, and G Damiani, and O Rosen, and M Scharff
GP43 from Paracoccidioides brasiliensis inhibits macrophage functions. An evasion mechanism of the fungus.
January 2002, Cellular immunology,
Copied contents to your clipboard!