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Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox. 2010
Maşallah Baran, and
Funda Özgenç, and
Ömer Berk, and
Demir Gökçe, and
Kaan Kavakli, and
Funda Yilmaz, and
Sait Şen, and
Raşit Vural Yağci
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, İzmir.
Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.
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