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Antibodies can protect against meningococcal infection by at least two mechanisms: complement-dependent serum bactericidal activity (SBA), and/ or opsonophagocytosis (OP), leading to destruction of the bacteria (1-4). Regarding group C meningococci, there seems to be a correlation between SBA activity and protection (1), whereas OP has been less well-studied. This function may have a supplementary or even major role in protection against group B meningococci.
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