-transparent.png){kind=logo}
Omega-dialkylaminoalkyl ethers of 3-exo-dialkylamino-(Z)-camphoroximes with antiarrhythmic and local anesthetic activities. 1990
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
Istituto di Scienze Farmaceutiche dell'Università Genova, Italy.
The synthesis of 3-exo-dialkylamino-(Z)-camphoroximes 7 starting from a mixture of 3-endo- and 3-exo-bromocamphornitrimine, hydroxylamine hydrochloride and excess secondary amine (dimethylamine, pyrrolidine, piperidine or morpholine) is described. Compounds 7 gave a series of omega-dialkylaminoalkyl ethers 9, 10 and 11 by reaction of 7 as sodium salts with omega-chloroalkyldialkylamines in DMF solution. Some of compounds 9, 10, 11 showed an appreciable antiarrhythmic and local anesthetic activity in rats and mice, respectively.
Related Publications
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
January 1991,
Farmaco (Societa chimica italiana : 1989),
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
July 1982,
Il Farmaco; edizione scientifica,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
May 1980,
Il Farmaco; edizione scientifica,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
April 1981,
Il Farmaco; edizione scientifica,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
October 1982,
Journal of medicinal chemistry,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
April 1990,
Farmaco (Societa chimica italiana : 1989),
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
May 1974,
Journal of medicinal chemistry,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
October 1957,
Scientia Sinica,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
January 1955,
Il Farmaco; edizione scientifica,
A Ranise, and
F Bondavalli, and
O Bruno, and
P Schenone, and
G Faillace, and
A Coluccino, and
W Filippelli, and
A Di Sarno, and
E Marmo
October 2012,
The Journal of organic chemistry,
