HE4 in the differential diagnosis of a pelvic mass: a case report. 2011

Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
Department of Molecular Medicine, Sapienza University, Rome 00161, Italy; E-Mails: scomploj@yahoo.it (S.C.); luigi.frati@uniroma1.it (L.F.); cecilia.midulla@uniroma1.it (C.M.).

Neoplasms of the ovary present an increasing challenge to the physician. Neoplastic ovarian cysts can resemble endometriomas in ultrasound imaging and need to be carefully considered in the differential diagnosis. We report the case of a woman with a strong family history of hereditary breast and ovarian cancer, who presented with a pelvic mass. The young girl refused oncogenetic counseling and genetic testing, even though she had a 50% a priori probability of being a BRCA1 mutation carrier. Pelvic magnetic resonance imaging (MRI) and a comparative analysis of the serum concentration of HE-4 and CA125 biomarkers provided accuracy and sensitivity in the diagnosis of a benign ovarian pathology. Based on this experience, we propose that the sensitivity of a screening program based on a HE4 and CA125 assay and MRI in high risk patients with mutations in the BRCA1 and BRCA2 genes may be considered a useful pre-operative tool for the differential diagnosis of pelvic masses.

UI MeSH Term Description Entries
D010048 Ovarian Cysts General term for CYSTS and cystic diseases of the OVARY. Corpus Luteum Cyst,Corpus Luteum Cysts,Cyst, Corpus Luteum,Cyst, Ovarian,Cysts, Corpus Luteum,Cysts, Ovarian,Ovarian Cyst
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000081102 WAP Four-Disulfide Core Domain Protein 2 A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer. Epididymal Secretory Protein E4,WFDC2 Protein,Protein, WFDC2,WAP Four Disulfide Core Domain Protein 2
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014408 Biomarkers, Tumor Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or BODY FLUIDS. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including HORMONES; ANTIGENS; amino and NUCLEIC ACIDS; ENZYMES; POLYAMINES; and specific CELL MEMBRANE PROTEINS and LIPIDS. Biochemical Tumor Marker,Cancer Biomarker,Carcinogen Markers,Markers, Tumor,Metabolite Markers, Neoplasm,Tumor Biomarker,Tumor Marker,Tumor Markers, Biochemical,Tumor Markers, Biological,Biochemical Tumor Markers,Biological Tumor Marker,Biological Tumor Markers,Biomarkers, Cancer,Marker, Biochemical Tumor,Marker, Biologic Tumor,Marker, Biological Tumor,Marker, Neoplasm Metabolite,Marker, Tumor Metabolite,Markers, Biochemical Tumor,Markers, Biological Tumor,Markers, Neoplasm Metabolite,Markers, Tumor Metabolite,Metabolite Markers, Tumor,Neoplasm Metabolite Markers,Tumor Markers, Biologic,Tumor Metabolite Marker,Biologic Tumor Marker,Biologic Tumor Markers,Biomarker, Cancer,Biomarker, Tumor,Cancer Biomarkers,Marker, Tumor,Markers, Biologic Tumor,Markers, Carcinogen,Metabolite Marker, Neoplasm,Metabolite Marker, Tumor,Neoplasm Metabolite Marker,Tumor Biomarkers,Tumor Marker, Biochemical,Tumor Marker, Biologic,Tumor Marker, Biological,Tumor Markers,Tumor Metabolite Markers
D018394 CA-125 Antigen A carbohydrate antigen that occurs in tumors of the ovary as well as in breast, kidney, and gastrointestinal tract tumors and normal tissue. While it is tumor-associated, it is not tumor-specific and may have a protective function against particles and infectious agents at mucosal surfaces. Antigen CA-125,CA 125 Antigen,Mucin-16,Antigen CA 125,Antigen, CA 125,Antigen, CA-125,Mucin 16

Related Publications

Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
December 1971, American journal of obstetrics and gynecology,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
November 2015, BMJ case reports,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
January 2017, Case reports in oncology,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
January 2003, Acta orthopaedica et traumatologica turcica,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
August 2010, La Tunisie medicale,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
January 2022, European journal of pediatric surgery reports,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
August 2015, Ceska gynekologie,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
August 1971, American journal of obstetrics and gynecology,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
January 2010, Journal of minimally invasive gynecology,
Emanuela Anastasi, and Teresa Granato, and Anna Coppa, and Lucia Manganaro, and Giuseppe Giannini, and Sara Comploj, and Luigi Frati, and Cecilia Midulla
January 2011, Journal of medical case reports,
Copied contents to your clipboard!