BIOMAT Database Logo BIOMAT Database Logo

Sinonasal abnormalities in patients with Graves' orbitopathy. 2011

Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston University, Boston, Massachusetts, USA.

OBJECTIVE To compare radiographic sinus mucosal thickening in patients with Graves' orbitopathy versus controls and determine whether target autoantigens thought to underlie systemic manifestations of Graves' disease are present within paranasal sinus mucosa. METHODS Case-control study. METHODS Sinus computed tomography (CT) scans from patients with Graves' orbitopathy scheduled for orbital decompression surgery (n = 50) were compared with maxillofacial CT scans from control patients (n = 50). Scans were rated for sinus mucosal disease by two independent reviewers using the Lund-MacKay and Harvard staging systems. Gene expression for thyrotropin receptor and type 1 insulin-like growth factor receptor (IGF-1R) was assessed in ethmoid mucosal samples using real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). RESULTS Increased sinus mucosal thickening was found in patients with Graves' orbitopathy compared with controls for both the Lund-MacKay (6.2 vs. 2.7; P < .01) and Harvard (2.1 vs. 1.3; P < .01) systems. Compared with control scans, the Graves' orbitopathy group exhibited greater mucosal thickening in the ethmoid, frontal, and sphenoid sinuses (P < .05 for all). RT-qPCR and IHC demonstrated gene expression for both the thyrotropin receptor and the IGF-1R in ethmoid mucosa. CONCLUSIONS Patients with Graves' orbitopathy who present for orbital decompression exhibit a higher prevalence of sinus mucosal thickening on CT scan. These findings may be explained by circulating autoantibodies to target antigens, thyrotropin receptor and IGF-1R, associated with Graves' disease and found to be expressed in sinus mucosa.

UI MeSH Term Description Entries
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009297 Nasal Mucosa The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells. Nasal Epithelium,Schneiderian Membrane,Epithelium, Nasal,Membrane, Schneiderian,Mucosa, Nasal
D010256 Paranasal Sinuses Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS. Nasal Sinuses,Osteomeatal Complex,Ostiomeatal Complex,Ostiomeatal Unit,Sinonasal Tract,Supraorbital Ethmoid Cell,Cell, Supraorbital Ethmoid,Complex, Osteomeatal,Ethmoid Cell, Supraorbital,Osteomeatal Complices,Ostiomeatal Complices,Ostiomeatal Units,Sinonasal Tracts,Sinuses, Nasal,Supraorbital Ethmoid Cells,Tract, Sinonasal
D011989 Receptors, Thyrotropin Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE). Receptors, Thyroid Stimulating Hormone,TSH Receptors,Thyroid Stimulating Hormone Receptors,Thyrotropin Receptors,LATS Receptors,Receptor, LATS Immunoglobulins,Receptors, LATS,Receptors, Long-Acting Thyroid Stimulator,Receptors, TSH,TSH Receptor,Thyroid Stimulating Hormone Receptor,Thyrotropin Receptor,Receptor, TSH,Receptor, Thyrotropin,Receptors, Long Acting Thyroid Stimulator
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D005260 Female Females
D006111 Graves Disease A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Concurrent myopathy in patients with Graves' orbitopathy.
January 2009, Orbit (Amsterdam, Netherlands),
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Management of sinonasal complications after endoscopic orbital decompression for Graves' orbitopathy.
September 2013, The Laryngoscope,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Facial expression of patients with Graves' orbitopathy.
October 2023, Journal of endocrinological investigation,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
[Graves' orbitopathy].
June 2006, Orvosi hetilap,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Graves' Orbitopathy.
January 2015, International journal of endocrinology,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
[Graves' orbitopathy].
May 2011, Klinische Monatsblatter fur Augenheilkunde,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Graves Orbitopathy.
June 2020, The Journal of the American Osteopathic Association,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
[Graves' Orbitopathy].
December 2016, Klinische Monatsblatter fur Augenheilkunde,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
Graves' orbitopathy.
February 2007, Ophthalmology,
Zachary M Soler, and Michael P Platt, and Man-Kit Leung, and Sandy Mong, and Ralph Metson
[Graves' orbitopathy].
October 2021, Deutsche medizinische Wochenschrift (1946),
Copied contents to your clipboard!