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PV-88 is the Ca2+ L channel blocker from pyrrole compounds, that has been used at hemorrhagic shock - HS (model of Shock was created by the method of (Wiggers-Feine) on 60th minute (intravenous administration, 3 mg/kg). Mean arterial pressure was 40 mmHg. Effects were studied on 80th minute after blood letting. Blood was exfused 40 ml/kg. Effect of PV-88 on redox processes in liver was studied. Experiments were carried out on male cats. Right lobe of the liver and the metabolic indices: ATP, CO, NAD, NADP, ALP, SDH, LDH were studied with the use of histochemistry (Pearse). Investigations have shown that on 80th minute after PV-88 administration CO (p<0.05), NADP (p<0.05), ALP (p<0.001), SDH (p<0.05), and LDH (p>0.05) were increased, while ATP (p<0.001) and NAD (p<0.001) were decreased. Increase in LDH was not statistically significant. According to the results of investigations, after administration of PV-88 at HS 60 on 80th minute, in liver increases oxygen concentration and aerobic process respectively.
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
August 1956,
Rivista di anatomia patologica e di oncologia,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
January 1972,
Acta chirurgica Scandinavica,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
January 1983,
International surgery,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
January 1946,
The American journal of physiology,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
July 1997,
Biulleten' eksperimental'noi biologii i meditsiny,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
May 2010,
Shock (Augusta, Ga.),
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
March 1994,
Masui. The Japanese journal of anesthesiology,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
November 2010,
The Journal of surgical research,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
January 1969,
Annals of surgery,
Gr Sulaberidze, and
M Ghvaladze, and
G Didava, and
B Kochlamazashvili, and
M Chkhaidze, and
T Gegeshidze
May 1983,
Nihon geka hokan. Archiv fur japanische Chirurgie,
