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Sixteen neonates, ranging in gestational age from 27 to 41 weeks and in postnatal age from birth to 8 days, were evaluated for their renal response to an endogenous PTH stimulus in 22 separate experiments. The PTH stimulus was generated by the decreased serum ionized Ca that accompanies exchange transfusion with citrated blood. The neonates increased their serum PTH from 95.8 +/- 13.1 to 133.9 +/- 15.4 microliterEq/ml (mean +/- SEM) during the transfusion, while increasing their urinary cAMP from 0.77 +/- 0.11 to 1.45 +/- 0.22 nmol/ml, and their urinary P from 12.9 +/- 2.6 to 30.6 +/- 6.1 mg/dl in the four hours following the exchange transfusion. This response was not related to postnatal or gestational age. We speculate that lack of renal responsiveness to PTH does not play a major role in the pathogenesis of early neonatal hypocalcemia.
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
January 1983,
General and comparative endocrinology,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
September 1981,
Clinica chimica acta; international journal of clinical chemistry,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
April 1975,
The Tohoku journal of experimental medicine,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
January 1978,
Scandinavian journal of urology and nephrology,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
January 1978,
Advances in experimental medicine and biology,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
April 1984,
The American journal of physiology,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
June 1980,
Nihon Naibunpi Gakkai zasshi,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
April 1976,
Calcified tissue research,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
March 1987,
Acta paediatrica Scandinavica,
D R Brown, and
E F Donovan, and
R C Tsang, and
C M Bobik, and
I W Chen, and
J R Johnson
May 1979,
Psychological medicine,
