Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women. 2011

Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Geoffrey.Kabat@einstein.yu.edu

OBJECTIVE Little is known about the risk factors for triple-negative breast cancer (TNBC), which has a worse prognosis compared to hormone receptor-positive breast cancer. We examined the association of smoking and alcohol intake with TNBC and estrogen receptor-positive (ER+) breast cancer. METHODS Among 148,030 women enrolled in the Women's Health Initiative, 300 TNBC cases and 2,479 ER+ cases were identified over a median of 8.0 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS Cigarette smoking was not associated with TNBC, whereas drinkers had reduced risk compared to never drinkers. In contrast, both exposures showed slight positive associations with ER+ breast cancer: for women with ≥ 40 pack-years of smoking, the HR was 1.24, 95% CI 1.06-1.44; for women consuming ≥ 7 servings of alcohol per week, the HR was 1.26, 95% CI 1.06-1.50. Intakes of wine and hard liquor were also significantly positively associated with ER+ breast cancer. CONCLUSIONS These findings from a large cohort of postmenopausal women suggest that smoking and alcohol consumption are not associated with increased risk of TNBC, but may be modestly associated with increased risk of ER+ breast cancer.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011960 Receptors, Estrogen Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important. Estrogen Receptor,Estrogen Receptors,Estrogen Nuclear Receptor,Estrogen Receptor Type I,Estrogen Receptor Type II,Estrogen Receptors Type I,Estrogen Receptors Type II,Receptor, Estrogen Nuclear,Receptors, Estrogen, Type I,Receptors, Estrogen, Type II,Nuclear Receptor, Estrogen,Receptor, Estrogen
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000428 Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. Alcohol Consumption,Alcohol Intake,Drinking, Alcohol,Alcohol Drinking Habits,Alcohol Drinking Habit,Alcohol Intakes,Consumption, Alcohol,Drinking Habit, Alcohol,Habit, Alcohol Drinking,Habits, Alcohol Drinking,Intake, Alcohol
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D012907 Smoking Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand. Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits

Related Publications

Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
November 1992, American journal of epidemiology,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
January 2000, Epidemiology (Cambridge, Mass.),
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
March 1994, American journal of epidemiology,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
December 1988, British journal of cancer,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
January 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
October 2018, International journal of cancer,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
February 1987, Journal of the National Cancer Institute,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
November 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
June 1995, Journal of the National Cancer Institute,
Geoffrey C Kabat, and Mimi Kim, and Amanda I Phipps, and Christopher I Li, and Catherine R Messina, and Jean Wactawski-Wende, and Lewis Kuller, and Michael S Simon, and Shagufta Yasmeen, and Sylvia Wassertheil-Smoller, and Thomas E Rohan
April 2014, British journal of cancer,
Copied contents to your clipboard!