-transparent.png){kind=logo}
Replication of herpes simplex virus takes place in the cell nucleus and is carried out by a replisome composed of six viral proteins: the UL30-UL42 DNA polymerase, the UL5-UL8-UL52 helicase-primase, and the UL29 single-stranded DNA-binding protein ICP8. The replisome is loaded on origins of replication by the UL9 initiator origin-binding protein. Virus replication is intimately coupled to recombination and repair, often performed by cellular proteins. Here, we review new significant developments: the three-dimensional structures for the DNA polymerase, the polymerase accessory factor, and the single-stranded DNA-binding protein; the reconstitution of a functional replisome in vitro; the elucidation of the mechanism for activation of origins of DNA replication; the identification of cellular proteins actively involved in or responding to viral DNA replication; and the elucidation of requirements for formation of replication foci in the nucleus and effects on protein localization.
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
August 2003,
IUBMB life,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
January 1997,
Annual review of biochemistry,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
October 1992,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
January 1995,
Biochimie,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
October 1999,
The Journal of biological chemistry,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
February 1989,
Nihon rinsho. Japanese journal of clinical medicine,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
January 1992,
Journal of virology,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
February 1976,
Virology,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
June 2002,
Journal of virology,
Isabella Muylaert, and
Ka-Wei Tang, and
Per Elias
May 1997,
Nucleic acids research,
