-transparent.png){kind=logo}
The value of 18F-fluoro-2'-deoxyuridine (18F-FUdR) as a tracer for nucleic acid metabolism was studied using an experimental rat brain-tumor model. The 18F activity in the tumor tissue 45 minutes after intravenous injection of 18F-FUdR was about 12 times higher than that in the contralateral cortex. Double-labeled autoradiography with 18F-FUdR and 14C-thymidine revealed similar brain-tumor images. In contrast, an autoradiographic comparison of 18F-FUdR with 14C-aminoisobutyric acid, which reveals the impairment of the blood-brain barrier, showed very different images. Also, the 18F radioactivity in the tumor tissue was at a constant level for 30 to 120 minutes, whereas a notable increase in 18F activity with time was observed in nucleotides and acid-insoluble fractions. These results suggest that the distribution pattern of 18F-FUdR closely correlates with the metabolism of nucleic acid and that this drug could be a useful tracer for positron emission tomography.
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
January 1989,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
October 2023,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
June 2001,
Japanese journal of clinical oncology,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
October 1963,
Experimental cell research,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
January 2008,
Journal of computer assisted tomography,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
June 2003,
Cancer biotherapy & radiopharmaceuticals,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
January 1994,
Drug metabolism and disposition: the biological fate of chemicals,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
April 2017,
Oncotarget,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
February 2005,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Y Tsurumi, and
M Kameyama, and
K Ishiwata, and
R Katakura, and
M Monma, and
T Ido, and
J Suzuki
March 1982,
The American journal of psychiatry,
