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Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short-latency (SL) and a long-latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the "gain" mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
April 1987,
Brain : a journal of neurology,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
January 1986,
Experimental brain research,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
February 1996,
Experimental brain research,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
May 1991,
Journal of neurophysiology,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
January 1990,
Electroencephalography and clinical neurophysiology. Supplement,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
June 1987,
Experimental neurology,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
December 1989,
The Journal of physiology,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
February 1993,
Electroencephalography and clinical neurophysiology,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
January 1983,
Neuroscience letters,
G Abbruzzese, and
D Dall'Agata, and
M Morena, and
L Spadavecchia, and
S Ratto, and
E Favale
December 1965,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
