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Embryonal rhabdomyosarcoma in a Rothschild's giraffe (Giraffa camelopardalis rothschildi). 2010

Margarita Woc-Colburn, and Suzan Murray, and Nancy Boedeker, and Tabitha Viner, and Michelle L Fleetwood, and Tony C Barthel, and Kurt D Newman, and Carlos R Sanchez
Smithsonian Institution's National Zoological Park, 3001 Connecticut Avenue NW, Washington, DC 20008-2598, USA. margarita_woc@yahoo.com

Abstract: A 3-yr-old male Rothschild's giraffe (Giraffa camelopardalis rothschildi) presented for acute swelling caudomedial to the left parietal horn. Following initial diagnostics and supportive treatment, the mass was surgically resected and intralesional chemotherapy was administered. Despite treatment, the giraffe's condition worsened and euthanasia was performed. Gross necropsy revealed neoplastic invasion and destruction of underlying parietal bone, adjacent horn base, and sinuses, and metastases in the tracheobronchial and mandibular lymph nodes and lung. Histologically, the tumor was composed of packets of anaplastic round cells. Immunohistochemical studies further characterized the tumor as an embryonal rhabdomyosarcoma. This is the first reported case of rhabdomyosarcoma in a giraffe.

UI MeSH Term Description Entries
D008297 Male Males
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000866 Antelopes Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn. Antelopines,Hippotragines,Antelope,Antelopine,Hippotragine
D012888 Skull Neoplasms Neoplasms of the bony part of the skull. Neoplasms, Skull,Neoplasm, Skull,Skull Neoplasm
D018233 Rhabdomyosarcoma, Embryonal A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The cells are smaller than those of other rhabdomyosarcomas and are of two basic cell types: spindle cells and round cells. This cancer is highly sensitive to chemotherapy and has a high cure rate with multi-modality therapy. (From Holland et al., Cancer Medicine, 3d ed, p2188) Embryonal Rhabdomyosarcoma,Embryonal Rhabdomyosarcomas,Rhabdomyosarcomas, Embryonal

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