-transparent.png){kind=logo}
The influence of cholinergic receptor blockade on the impedance of the respiratory system was studied in 10 healthy volunteers in a frequency spectrum between 4 and 52 Hz by means of the forced pseudo random-noise oscillation technique. Ipratropium bromide was used in the inhaled form in two doses (0.040 and 0.200 mg). Both does caused a significant decrease in oscillatory airway resistance, Rrs. No dose effect on Rrs was found. Both doses caused an increase in the reactance of the respiratory system, Xrs. This increase in Xrs was significantly greater after the inhalation of the higher dose. The effect of both doses on the real part of impedance can be explained by a dilation of the central airways. Furthermore, inhaled ipratropium bromide, especially in the higher dose, led to an increase in the imaginary part of impedance suggesting a decrease in the capacitance of pulmonary structures in normal subjects.
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
January 1987,
Chest,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
October 1987,
Thorax,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
May 1989,
Chest,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
June 1997,
Chest,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
April 1980,
Medicina clinica,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
October 1981,
British journal of clinical pharmacology,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
March 1989,
International journal of clinical pharmacology, therapy, and toxicology,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
April 1988,
Thorax,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
September 1992,
British journal of clinical pharmacology,
G J Wesseling, and
J M Vonk, and
L H Greve, and
E F Wouters
December 1980,
Nippon Ganka Gakkai zasshi,
