BIOMAT Database Logo BIOMAT Database Logo

Significant association of caveolin-1 (CAV1) genotypes with prostate cancer susceptibility in Taiwan. 2011

Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Department of Urology, China Medical University Hospital, Taichung, Taiwan, ROC.

BACKGROUND Multiple lines of evidence have implicated the Caveolin-1 (CAV1) gene in prostate cancer progression. CAV1 is located within the locus at 7q31-33 associated with prostate cancer aggressiveness, and was identified as being overexpressed in prostate tumors. Therefore, this study evaluated the relationship between the polymorphism of CAV1 and the risk of prostate cancer in Taiwan. METHODS Two hundred and fifty patients with prostate cancer and five hundred age-matched healthy controls recruited were genotyped. RESULTS There were significant differences between prostate cancer and control groups in the distributions of their genotypes (p = 0.0004) and allelic frequencies (p = 4.9 × 10(-5)) in the CAV1 T29107A (rs7804372) polymorphisms. CONCLUSIONS This study provides evidence for the relationship of this variant of CAV1 and risk of prostate cancer which might merit further study as a genomic marker for early detection of prostate cancer.

UI MeSH Term Description Entries
D008297 Male Males
D011471 Prostatic Neoplasms Tumors or cancer of the PROSTATE. Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D002897 Chromosomes, Human, Pair 7 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 7
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D051242 Caveolin 1 A tyrosine phosphoprotein that plays an essential role in CAVEOLAE formation. It binds CHOLESTEROL and is involved in LIPIDS transport, membrane traffic, and SIGNAL TRANSDUCTION. Caveolin-1,VIP21 Protein,Vesicular Integral Membrane Protein 21 kDa,alpha-Caveolin,beta-Caveolin,alpha Caveolin,beta Caveolin
D020022 Genetic Predisposition to Disease A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. Genetic Predisposition,Genetic Susceptibility,Predisposition, Genetic,Susceptibility, Genetic,Genetic Predispositions,Genetic Susceptibilities,Predispositions, Genetic,Susceptibilities, Genetic
D020641 Polymorphism, Single Nucleotide A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population. SNPs,Single Nucleotide Polymorphism,Nucleotide Polymorphism, Single,Nucleotide Polymorphisms, Single,Polymorphisms, Single Nucleotide,Single Nucleotide Polymorphisms

Related Publications

Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Significant association of caveolin-1 genotypes with bladder cancer susceptibility in Taiwan.
June 2011, The Chinese journal of physiology,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
The association of Caveolin-1 genotypes with oral cancer susceptibility in Taiwan.
May 2011, Annals of surgical oncology,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Association of caveolin-1 genotypes with nasopharyngeal carcinoma susceptibility in Taiwan.
October 2011, Anticancer research,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Association of caveolin-1 genotypes with gastric cancer in Taiwan.
May 2014, Anticancer research,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression.
January 2015, Cancer genomics & proteomics,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.
August 2010, World journal of gastrointestinal oncology,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Significant association of Interleukin-10 genotypes and oral cancer susceptibility in Taiwan.
July 2014, Anticancer research,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Significant association of DNA repair gene Ku80 genotypes with breast cancer susceptibility in Taiwan.
December 2009, Anticancer research,
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan.
January 2021, In vivo (Athens, Greece),
Hsi-Chin Wu, and Chao-Hsiang Chang, and Yung-An Tsou, and Chia-Wen Tsai, and Cheng-Chieh Lin, and Da-Tian Bau
The Significant Association of MMP-1 Genotypes With Taiwan Pterygium.
February 2020, Anticancer research,
Copied contents to your clipboard!