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Plasma levels of atrial natriuretic peptide (ANP) and the effect of exogenous ANP on renal function have been studied in newborn and adult rabbits. In order to investigate an age difference in responsiveness to ANP, we studied the renal effects of alpha-human ANP (1-28) administered at the same dose per kg body weight in adult and neonatal rabbits. Plasma basal ANP levels were similar in 18 newborn (4- to 11-day-old) compared to 7 adult rabbits (150 +/- 16 and 151 +/- 28 pg/ml, resp.). Eleven newborn and 11 adult rabbits were anesthetized and mechanically ventilated. After a control period, each animal received an hANP loading dose (3 micrograms/kg i.v.), followed by an infusion of 0.3 micrograms/kg/min. Blood gases remained stable throughout the experiment in both groups. Mean blood pressure decreased in newborn (28.5 +/- 0.8 to 26.2 +/- 1.0 mmHg) and adult (92 +/- 3 to 84 +/- 3 mmHg) animals. Percent hANP-induced changes in renal functions in newborn and adult rabbits were, respectively: urine flow rate: -21 +/- 4% and +57 +/- 8%; urinary sodium excretion: +4 +/- 7% and +81 +/- 11%; glomerular filtration rate (GFR): -19 +/- 4% and -4 +/- 6%; renal blood flow (RBF): -22 +/- 4% and -11 +/- 5%. As expected, diuresis and natriuresis increased in adult rabbits. Failure of hANP to increase natriuresis and diuresis in newborn rabbits could be related to the marked decrease in GFR, receptor immaturity and/or interactions with other hormonal systems.
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
January 1989,
The Japanese journal of physiology,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
January 1987,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
February 1987,
The American journal of physiology,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
November 1987,
The American journal of physiology,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
October 1993,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
April 1992,
Clinical and investigative medicine. Medecine clinique et experimentale,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
January 1989,
Clinical and experimental hypertension. Part A, Theory and practice,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
May 1995,
The journals of gerontology. Series A, Biological sciences and medical sciences,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
January 1988,
Neuropeptides,
B A Semmekrot, and
P H Wiesel, and
L A Monnens, and
J P Guignard
March 1990,
The Journal of pharmacology and experimental therapeutics,
