Retroviral Transfer of the Herpes Simplex Virus-Thymidine Kinase (HSV-tK) Gene for the Treatment of Cancer. 2000

R Ramesh, and A Munshi, and A J Marrogi, and S M Freeman
Department of Thoracic and Cardiovascular Surgery, M.D. Anderson Cancer Center, Houston, TX.

Gene therapy is defined as the alteration of the genetic material of a cell with resultant benefit to a patient. Gene transfer has two broad categories: one in which a therapeutic gene is delivered to the cells with the aim of treating a disease; and another where a marker gene is delivered to label a cell type to determine the fate of a cell or the marker gene. Gene therapy is now becoming a rapidly developing therapeutic modality for experimental treatment of some cancers and diseases that have no alternative treatment (1,2).

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