Biomaterial Database

Abnormal glucose tolerance: a predictor of 30-day mortality in patients with decompensated liver cirrhosis. 2011

S Hagel, and T Bruns, and A Herrmann, and A Stallmach, and C Schmidt

Division of Gastroenterology, Hepatology, and Infectious Diseases, Department of Internal Medicine II, Friedrich-Schiller-University, Jena, Germany.

BACKGROUND In liver cirrhosis an abnormal glucose tolerance correlates with a poor long-term prognosis. The aim of this study was to evaluate whether a disturbed glucose metabolism predicts the short-term prognosis in hospitalized patients with decompensated liver cirrhosis. METHODS Seventy-eight patients with liver cirrhosis were prospectively enrolled. Disturbed glucose metabolism was determined by a 75-g oral glucose tolerance test (OGTT) according to WHO criteria. Differences in survival were assessed by χ (2) test for 30-day mortality and by multivariate Cox proportional hazards analysis for long-term survival. RESULTS Impaired glucose tolerance (IGT) was diagnosed in 29 patients (37 %) and diabetes mellitus (DM) in 26 patients (33 %). A pathological OGTT result was a significant negative predictor of a poor 30-day survival compared to NGT (OR 8.6; p=0.03). DM but not IGT was an independent negative predictor of long-term survival (HR=1.89; p=0.04). CONCLUSIONS Disturbed glucose metabolism in hospitalized patients with decompensated liver cirrhosis is correlated with increased 30-day mortality. OGTT appears to be useful for identifying cirrhotic patients with poor short term prognosis.

UI	MeSH Term	Description	Entries
D008103	Liver Cirrhosis	Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.	Cirrhosis, Liver,Fibrosis, Liver,Hepatic Cirrhosis,Liver Fibrosis,Cirrhosis, Hepatic
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D003920	Diabetes Mellitus	A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D005260	Female		Females
D005858	Germany	A country in central Europe, bordering the Baltic Sea and the North Sea, between the Netherlands and Poland, south of Denmark. The capital is Berlin.
D005951	Glucose Tolerance Test	A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).	Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor